This is an attempt to characterise the Mediterranean region in biogeographic-historic terms, and not the usual climatic ones. "Mediterraneis "is a province contained between the Sahara and the Alpine mountain ridges, with the Mediterranean Sea, the only remnant ofthe Mesozoic Tethys as its core. The fauna and flora of the province is composed of Palearctic and some Ethiopian biota which evolved during the late Neogene, in the refuges of the sea shore and on the many islands. There has been a tight relation with the hydrological evolution of the Mediterranean sea, culminating with the paroxysm of the Messinian event. Information on floristics and faunistics is being compared. Characteristically foro this province, ear1y seafaring co-existed already with post-Glacial climate fluctuations and tectonic conflagrations Peculiar circumMediterranean distribution areas resulted from prolonged human impact. Cycles of frequent and sudden altemations of humid to arid climates, jointly with the anthropic impact moulded this province. The modem Suez Canal and river-damming have al so radically changed marine life.